USS Weiss (DE-378)

The first USS Weiss (DE-378), was John C. Butler-class destroyer escort proposed for construction during World War II but never completed.

Weiss was named after United States Marine Corps sergeant Carl Walter Weiss, who was killed in action during a battle on 1 November 1942 with Japanese forces near the Matanikau River on Guadalcanal, when he charged an enemy machine gun position and destroyed it with a hand grenade. For "his great personal valor, aggressiveness and fine spirit of self sacrifice," Sergeant Weiss was awarded the Navy Cross posthumously.

Weiss was cancelled on 5 June 1944 before completion, and her materials were scrapped.

The name Weiss was reassigned to a Rudderow-class destroyer escort, USS Weiss (DE-719), which was converted during construction into the Crosley-class fast transport USS Weiss (APD-135).