Melisende of Lusignan

Melisende de Lusignan, Princess of Antioch (1200 Holy Land- after 1249), was the youngest daughter of Queen Isabella I of Jerusalem by her fourth and last marriage to King Amalric II of Jerusalem. She had a sister Sibylla of Lusignan, a younger brother, Amalric who died as a young child. By her mother's previous marriages, Melisande had three half-sisters, Maria of Montferrat, who succeeded their mother as queen of Jerusalem on 5 April 1205; Alice of Champagne, and Philippa of Champagne.

Marriage and issue
In January 1218, Melisande married as his second wife, Bohemond IV, Prince of Antioch. The marriage produced three daughters: Melisende protested the succession of her nephew King Henry I of Cyprus as regent of Jerusalem on the death of her half-sister Alice in 1246. Alice had been regent of Jerusalem for Conrad IV of Germany.
 * Isabelle of Antioch (died young)
 * Marie of Antioch (died after 10 December 1307), she was childless.
 * Helvis of Antioch (died young)

She died sometime after 1249. Upon the childless death of her only surviving daughter, Marie sometime after December 1307, the line of Melisende became extinct.