USS Wilkes

USS Wilkes may refer to:


 * USS Wilkes (TB-35), a torpedo boat which served around the turn of the 20th century


 * USS Wilkes (DD-67), a destroyer which served during World War I


 * USS Wilkes (DD-441), a destroyer which served during World War II


 * USS Wilkes-Barre (CL-103), a light cruiser which served during World War II