USS Defiance

USS Defiance may refer to:


 * USS Defiance (ID-3327), a cargo vessel in service from 1918–1919
 * USS Defiance (AMc-73), a coastal minesweeper that served during World War II
 * USS Defiance (PG-95), a patrol gunboat that served from 1969 until 1973 when it was transferred to Turkey


 * Other
 * USS Point Defiance (LSD-31)
 * USS Defiant (YT-804)