English ship St Andrew (1622)

St Andrew was a 42-gun great ship of the English Royal Navy (subsequently second rate), built by Andrew Burrell at Deptford and launched in 1622.

She was known as Andrew during the Commonwealth. During the English Civil War, the Andrew was involved in fighting against the last Royalist holdouts in Cornwall. In a letter dated June 30, 1646, ship's Parliamentary commander, a man named W. Batten, wrote to his superior "Sir, I believe the castle of Pendennis will not be long out of our hands; a dogger boat with four guns I have taken, whereof one Kedgwin of Penzant was captain, a notable active knave against the Parliament, and had the King's commission; and now would fain be a merchant man, and was balasted with salt and had divers letters in her for Pendennis castle..." At the Restoration, the Andrew passed to serving the restored King and resumed her original name, St Andrew.

By 1660, she was armed with 56 guns.

St Andrew was wrecked in 1666.