Frederick Banting

Sir Frederick Grant Banting, KBE, MC, FRS, FRSC (November 14, 1891 – February 21, 1941) was a Canadian medical scientist, doctor, painter and Nobel laureate noted as the primary discoverer of insulin.

In 1923 Banting and John James Rickard Macleod received the Nobel Prize in Medicine. Banting shared the award money with his colleague, Dr. Charles Best. , Banting, who received the Nobel Prize at age 32, remains the youngest Nobel laureate in the area of Physiology/Medicine. The Canadian government gave him a lifetime annuity to work on his research. In 1934 he was knighted by King George V. In 2004, Frederick Banting was voted fourth place on The Greatest Canadian.

Early years
Frederick Banting was born on November 14, 1891, in a farm house near Alliston, Ontario. The youngest of five children (Nelson, Thompson, Kenneth and Essie) of William Thompson Banting and Margaret Grant, he attended public and high schools in Alliston. He attempted to enter the army but was refused due to poor eyesight. He then attended the University of Toronto in the faculty of divinity but soon transferred to medicine. He received his M.B. degree in 1916 and enlisted in the Canadian Army Medical Corps, which had a need for medics in World War I. He was wounded at the battle of Cambrai in 1918. Despite his injuries, he helped other wounded men for sixteen hours, until another doctor told him to stop. He was awarded the Military Cross in 1919, for heroism.

Banting returned to Canada after the war and briefly took up general practice in London, Ontario. Returning to Toronto, he studied orthopaedic medicine and, in 1919–1920, was Resident Surgeon at the Hospital for Sick Children. From 1920–21, he continued his general practice, while teaching orthopedics and anthropology part-time at the University of Western Ontario in London. From 1921–22 he lectured in pharmacology at the University of Toronto, receiving his M.D. degree in 1922, along with a gold medal.

Scientific studies
An article he read about the pancreas piqued Banting's interest in diabetes. Research by Naunyn, Minkowski, Opie, Schafer, and others suggested that diabetes resulted from a lack of a protein hormone secreted by the islets of Langerhans in the pancreas. Schafer had named this hormone insulin. Insulin was thought to control the metabolism of sugar; its lack led to an increase of sugar in the blood which was then excreted in urine. Attempts to extract insulin from ground-up pancreas cells were unsuccessful, likely because of the destruction of the insulin by the proteolysis enzyme of the pancreas. The challenge was to find a way to extract insulin from the pancreas prior to its being destroyed.

Moses Barron published an article on experimental closure of the pancreatic duct by ligature which further influenced Banting's thinking. The procedure caused deterioration of the cells of the pancreas that secrete trypsin but left the islets of Langerhans intact. Banting realized that this procedure would destroy the trypsin-secreting cells but not the insulin. Once the trypsin-secreting cells had died, insulin could be extracted from the islets of Langerhans. Banting discussed this approach with J. J. R. Macleod, Professor of Physiology at the University of Toronto. Macleod provided experimental facilities and the assistance of one of his students, Dr. Charles Best. Banting and Best began the production of insulin by this means.

Banting was appointed Senior Demonstrator in Medicine at the University of Toronto in 1922. The following year he was elected to the new Banting and Best Chair of Medical Research, endowed by the Legislature of the Province of Ontario. He also served as Honorary Consulting Physician to the Toronto General, the Hospital for Sick Children, and the Toronto Western Hospital. At the Banting and Best Institute, he researched silicosis, cancer, and the mechanisms of drowning. During the Second World War he investigated the problems of aviators, such as "blackout" (syncope).

Personal life
Banting developed an interest in painting beginning around 1921 while he was in London, Ontario. He became friends with Group of Seven artists A. Y. Jackson and Lawren Harris, sharing their love of the rugged Canadian landscape. In 1927 he made a sketching trip with Jackson to the St. Lawrence in Quebec. Later that year they traveled to RCMP outposts in the Arctic on the Canadian Government supply ship Beothic. The sketches, done both in oils on birch panels and in pen and ink, were named after the places he visited: Craig Harbour, Ellesmere Island; Pond Inlet, Baylot Island; Eskimo tents at Etach; others were untitled. Jackson and Banting also made painting expeditions to Great Slave Lake, Walsh Lake (Northwest Territories), Georgian Bay, French River and the Sudbury District.

Banting married twice. His first marriage was to Marion Robertson in 1924; they had one child, William (b. 1928). They divorced in 1932 and Banting married Henrietta Ball in 1937.

In 1938, Banting's interest in aviation medicine resulted in his participation with the Royal Canadian Air Force (RCAF) in research concerning the physiological problems encountered by pilots operating high-altitude combat aircraft. Banting headed the RCAF's Number 1 Clinical Investigation Unit (CIU), which was housed in a secret facility on the grounds of the former Eglinton Hunt Club in Toronto.

In February 1941, Banting died of wounds and exposure following a Lockheed L-14 Super Electra/Hudson crash in Musgrave harbourNewfoundland. He was en route to England to conduct operational tests on the Franks flying suit developed by his colleague Wilbur Franks.

Banting and his wife are buried at Mount Pleasant Cemetery in Toronto.

Legacy
Banting's name is immortalised in the yearly Banting Lectures, given by an expert in diabetes, and by the creation of the Banting and Best Department of Medical Research of the University of Toronto; Banting Memorial High School in Alliston, ON; Sir Frederick Banting Secondary School in London, ON; Sir Frederick Banting Alternative Program Site in Ottawa, ON; Frederick Banting Elementary School in Montreal-Nord QC and École Banting Middle School in Coquitlam, BC. Banting House, his house in London, Ontario, was declared a National Historic Site of Canada in 1997. The Banting Interpretation Centre in Musgrave Harbour, Newfoundland and Labrador is a museum named after him which focuses on the circumstances surrounding the 1941 plane crash which claimed his life. The crater Banting on the Moon is also named after his brother.

In 1994 Banting was inducted into the Canadian Medical Hall of Fame. In 2004, he was nominated as one of the top 10 "Greatest Canadians" by viewers of the Canadian Broadcasting Corporation. When the final votes were counted, Banting finished fourth behind Tommy Douglas, Terry Fox and Pierre Trudeau.

During the voting for "Greatest Canadians" in late 2003, controversy rose over the future use of the Banting family farm in New Tecumseth which had been left to the Ontario Historical Society by Banting's late nephew, Edward, in 1998. The dispute centred around the future use of the 40 ha (100 acre) property and its buildings. In a year-long negotiation, assisted by a provincially-appointed facilitator, the Town of New Tecumseth offered $1 million to the Ontario Historical Society (OHS). The town intended to turn the property over to the Sir Frederick Banting Legacy Foundation for preservation of the property and buildings, and the Legacy Foundation planned to erect a Camp for Diabetic Youths. The day after the November 22, 2006 deadline for the OHS to sign the agreement, the OHS announced that it had sold the property for housing development to Solmar Development for more than $2 million.

The Town of New Tecumseth announced it would designate the property under the Ontario Heritage Act. This would prevent its commercial development and obligate the owner to maintain it properly. OHS objected. The Ontario Conservation Review Board heard arguments for and against designation in September, 2007 and recommended designation of the entire 100 acre property in October. The Town officially passed the designation by-law on November 12, 2007.

In January, 2007, insulin was named first in a cross-Canada survey by the CBC to identify the 10 Greatest Canadian Inventions. A painting of his called "St. Tîte des Cap" sold for CDN$30,000 including buyer's premium at a Canadian Art auction in Toronto. The 1988 television movie Glory Enough for All depicted the search for insulin by Banting and Best, with R. H. Thomson starring as Banting. Banting is also portrayed by Jason Priestley boarding his fatal flight in the 2006 historical drama Above and Beyond.

The "Major Sir Frederick Banting, MC, RCAMC Award for Military Health Research", sponsored by the True Patriot Love Foundation, is awarded annually by the Surgeon General to the researcher whose work presented at the annual Military and Veterans Health Research Forum is deemed to contribute most to military health. It was first awarded in 2011 in the presence of several Banting descendants.

The "Canadian Forces Major Sir Frederick Banting Term Chair in Military Trauma Research" at Sunnybrook Health Sciences Centre was established in 2012. The first Chair holder is Colonel Homer Tien, Medical Director of Sunnybrook's Tory Regional Trauma Centre and Senior Specialist and Trauma Adviser to the Surgeon General.

The Government of Canada administers the "Banting Postdoctoral Fellowship Program", one of the most prestigious early-career academic awards in the world.

Awards and honours
Prior to the award of the Nobel Prize in Physiology or Medicine for 1923—which he shared with Macleod—he received the Reeve Prize of the University of Toronto (1922). In 1923, the Canadian Parliament granted him a Life Annuity of $7,500. In 1928 Banting gave the Cameron Lecture in Edinburgh. He was a member of numerous medical academies and societies in Canada and abroad, including the British and American Physiological Societies, and the American Pharmacological Society. In 1934 he was knighted as a Knight Commander of the Order of the British Empire (KBE) and became an active Vice-President of the Diabetic Association (now Diabetes UK). In May, 1935 he was elected a Fellow of the Royal Society.

Flame of Hope
A flame of hope was lit in 1989 as a tribute to Dr. Frederick Banting and all the people that have lost their lives to diabetes. The flame will remain lit until there is a cure for diabetes. The flame is located at Sir Fredrick Banting Square in London, Ontario, Canada.

Honorary degrees
Sir Frederick Banting received honorary degrees from several Universities:
 * University of Western Ontario in London, Ontario (LL.D.) on 30 May 1924
 * University of Toronto in Toronto, Ontario (D.Sc.) in 1924
 * Queen's University in Kingston, Ontario (LL.D) in 1924
 * University of Michigan in Ann Arbor, Michigan (LL.D.) in 1924
 * Yale University in New Haven, Connecticut (Sc.D.) in 1924
 * University of the State of New York (D.Sc.) in 1931
 * McGill University in Montreal, Quebec (D.Sc.) in 1939