USS Preble

USS Preble may refer to:


 * USS Preble (1813) was a sloop-of-war that fought at the Battle of Lake Champlain in the War of 1812
 * USS Preble (1839), was a sloop that fought in the Mexican-American War and the Civil War, and visited Japan. She was accidentally destroyed by fire in 1863
 * USS Preble (DD-12), launched in 1901, was a Bainbridge-class destroyer that served in World War I
 * USS Preble (DD-345), launched in 1920, was a Clemson-class destroyer that served in the Pacific campaign of World War II
 * USS Preble (DDG-46), launched in 1959; decommissioned 1991, was a Farragut-class guided missile destroyer which saw action in the Vietnam War.
 * USS Preble (DDG-88), launched in 2001, is an Arleigh Burke-class destroyer currently in commission