German submarine U-881

German submarine U-881 was a Type IXC/40 U-boat of the German Navy during World War II. The ship was ordered on 26 April 1942, laid down on 7 August 1943, and launched on 4 March 1944. She was commissioned into the Kriegsmarine under the command of Kplt. Dr. Karl-Heinz Frischke on 27 May 1944. Initially assigned to the 4th U-boat Flotilla, she was transferred to the 33rd U-boat Flotilla on 1 March 1945.

For her first patrol, U-881 was assigned to operate in US coastal waters with wolf pack Seewolf. During this operation U-881 was depth charged and sunk by the American destroyer escort USS Farquhar (DE-139) on 6 May 1945 in one of the last actions in American waters of the Atlantic campaign. She sank at position 43.3°N, -47.73333°W with the loss of all 54 men on board.