German submarine U-163

U-163 may refer to one of the following German submarines:


 * SMU U-163 (SM ''U-163), a Type Mittel U submarine launched in 1918; served in World War I until surrendered on 22 November 1918; broken up at La Spezia in August 1919
 * GS U-163 (1941)), a Type IXC submarine that served in World War II until sunk on 13 March 1943