506th may refer to:
- 506th Air Expeditionary Group, provisional United States Air Force unit
- 506th Air Refueling Squadron, inactive United States Air Force unit
- 506th Airborne Infantry Regiment Association, charitable veterans' organization
- 506th Bombardment Squadron, inactive United States Air Force unit
- 506th Fighter Squadron, unit of the Oklahoma Air National Guard that flies the KC-135 Stratotanker
- 506th Infantry Regiment (United States), unit assigned to the 4th Brigade Combat Team (BCT) of the 101st Airborne Division
- E Company, 506th Infantry Regiment (United States), the "Screaming Eagles", one of the most well-known companies in the United States Army
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