- Santiago del Estero (S-2), built in Italy and commissioned in 1933, served until 1960
- Santiago del Estero (S-12), formerly USS Lamprey (SS-372), commissioned in 1960 and served until 1971
- Santiago del Estero (S-22), formerly USS Chivo (SS-341), commissioned in 1971 and served until 1981
- Santiago del Estero (S-44), is an TR-1700 class submarine that was never completed due to the Argentine economic crisis of the 1980s
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