The Battle of Pelusium may refer to:
- Battle of Pelusium (525 BC), first battle fought between Achaemenid forces under Cambyses II of Persia and Psamtik III of Egypt, leading to defeat of the Egypt's Twenty-six dynasty and the first Persian period in Egypt
- Battle of Pelusium (343 BC), second battle fought between Achaemenid forces under Artaxerxes III (the Ochus) of Persia and pharaoh Nectanebo II, leading to defeat of Egyptian forces and the start of second Persian period in Egypt
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