Fokker built 65 for U.S. commercial and military service. After the crash of TWA Flight 599 in 1931, which was caused in part by the deterioration of the wooden structure in the F.10's wing, the type was temporarily grounded, and it was required to undergo more frequent and rigorous inspection and maintenance. Its public image was also greatly damaged, leading to its early retirement from U.S. airlines.
On June 10, 1929, a Pan Am F.10, registration NC9700 and named Cuba, struck telephone wires and crashed while taking off from Santiago de Cuba bound for Havana, killing two of five on board. The aircraft failed to gain altitude due to a waterlogged runway.
On March 31, 1931, TWA Flight 599 crashed near Bazaar, Kansas after a wing separated in flight, killing all eight on board, including football coach Knute Rockne.
On March 19, 1932, an American Airways F.10A, registration NC652E, struck power lines in heavy fog and crashed into an orchard near Calimesa, California, killing all seven on board.
On September 8, 1932, an American Airways F.10, registration NC9716, crashed into a mountain in poor weather near Salt Flat, Texas, killing three of four on board.