- USS Little (DD-79), was a Wickes-class destroyer, launched in 1918. In 1940 she was later redesignated a high-speed transport, APD-4. She was sunk in action off Guadalcanal in 1942.
- USS Little (DD-803), was a Fletcher-class destroyer, launched in 1944. She was sunk in action during the Battle of Okinawa in 1945.
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