USS Wilkes may refer to:
- USS Wilkes (TB-35), a torpedo boat which served around the turn of the 20th century
- USS Wilkes (DD-67), a destroyer which served during World War I
- USS Wilkes (DD-441), a destroyer which served during World War II
- USS Wilkes-Barre (CL-103), a light cruiser which served during World War II
|This article includes a list of ships with the same or similar names. If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship article, if one exists.|
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